Juegos de ida:
28.09.2010 | 21.15hs. (00.15+ GMT) | Defensor Sporting (URU) 1 - 0 Independiente (ARG)
29.09.2010 | 21.15hs. (00.15+ GMT) | CA Banfield (ARG) 2 - 0 Deportes Tolima (COL)
06.10.2010 | 21.15hs. (00.15+ GMT) | Newell's Old Boys 6 - 0 San José (BOL)
12.10.2010 | 20.15hs. (23.15 GMT) | Unión San Felipe (CHI) vs. Liga de Quito (ECU)
13.10.2010 | 19.30hs. (22.30 GMT) | Goiás EC (BRA) vs. Peñarol (URU)
13.10.2010 | 22.00hs. (01.00+ GMT) | Atl. Mineiro (BRA) vs. Indep. Santa Fe (COL)
13.10.2010 | 20.00hs. (01.00+ GMT) | Emelec (ECU) vs. Avaí FC (BRA)
14.10.2010 | 20.15hs. (00.15+ GMT) | Universitario de Sucre (BOL) vs. Palmeiras (BRA)
Juegos de revancha:
12.10.2010 | 20.30hs. (01.30+ GMT) | Deportes Tolima (COL) vs. CA Banfield (ARG)
19.10.2010 | 19.20hs. (22.30 GMT) | Independiente (ARG) vs. Defensor Sporting (URU)
19.10.2010 | 20.00hs. (01.00+ GMT) | Liga de Quito (ECU) vs. Unión San Felipe (CHI)
20.10.2010 | 19.30hs. (21.30 GMT) | Peñarol (URU) vs. Goiás EC (BRA)
20.10.2010 | 22.00hs. (00.00+ GMT) | Palmeiras (BRA) vs. Universitario de Sucre (BOL)
20.10.2010 | 19.00hs. (00.00+ GMT) | Indep. Santa Fe (COL) vs. Atl. Mineiro (BRA)
21.10.2010 | 20.15hs. (22.15 GMT) | Avaí FC (BRA) vs. Emelec (ECU)
21.10.2010 | 20.45hs. (00.45+ GMT) | San José (BOL) vs. Newell's Old Boys (ARG)
